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Article

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma.

Blood - 1 Mar 2012

Kridel Robert, Meissner Barbara, Rogic Sanja, Boyle Merrill, Telenius Adele, Woolcock Bruce, Gunawardana Jay, Jenkins Catherine E, Cochrane Chris, Ben-Neriah Susana, Tan King, Morin Ryan D, Opat Stephen, Sehn Laurie H, Connors Joseph M, Marra Marco A, Weng Andrew P, Steidl Christian, Gascoyne Randy D

Abstract excerpt

Mantle cell lymphoma (MCL), an aggressive subtype of non-Hodgkin lymphoma, is characterized by the hallmark translocation t(11;14)(q13;q32) and the resulting overexpression of cyclin D1 (CCND1). Our current knowledge of this disease encompasses frequent secondary cytogenetic aberrations and the recurrent mutation of a handful of genes, such as TP53, ATM, and CCND1. However, these findings insufficiently explain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin D1

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Source

Identifiers

PMID: 22210878
DOI: 10.1182/blood-2011-11-391474

Genes

NOTCH1
CCND1
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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