Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes.

doi:10.1182/blood.2020005289

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Article

Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes.

Blood - 17 Sept 2020

Nadeu Ferran, Martin-Garcia David, Clot Guillem, Díaz-Navarro Ander, Duran-Ferrer Martí, Navarro Alba, Vilarrasa-Blasi Roser, Kulis Marta, Royo Romina, Gutiérrez-Abril Jesús, Valdés-Mas Rafael, López Cristina, Chapaprieta Vicente, Puiggros Montserrat, Castellano Giancarlo, Costa Dolors, Aymerich Marta, Jares Pedro, Espinet Blanca, Muntañola Ana, Ribera-Cortada Inmaculada, Siebert Reiner, Colomer Dolors, Torrents David, Gine Eva, López-Guillermo Armando, Küppers Ralf, Martin-Subero Jose I, Puente Xose S, Beà Sílvia, Campo Elias

Abstract excerpt

Mantle cell lymphoma (MCL) is a mature B-cell neoplasm initially driven by CCND1 rearrangement with 2 molecular subtypes, conventional MCL (cMCL) and leukemic non-nodal MCL (nnMCL), that differ in their clinicobiological behavior. To identify the genetic and epigenetic alterations determining this diversity, we used whole-genome (n = 61) and exome (n = 21) sequencing (74% cMCL, 26% nnMCL) combined with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 32584970
DOI: 10.1182/blood.2020005289
PMCID: PMC7498364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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