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Article

The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells.

Blood - 8 May 2014

Zhang Jenny, Jima Dereje, Moffitt Andrea B, Liu Qingquan, Czader Magdalena, Hsi Eric D, Fedoriw Yuri, Dunphy Cherie H, Richards Kristy L, Gill Javed I, Sun Zhen, Love Cassandra, Scotland Paula, Lock Eric, Levy Shawn, Hsu David S, Dunson David, Dave Sandeep S

Abstract excerpt

In this study, we define the genetic landscape of mantle cell lymphoma (MCL) through exome sequencing of 56 cases of MCL. We identified recurrent mutations in ATM, CCND1, MLL2, and TP53. We further identified a number of novel genes recurrently mutated in patients with MCL including RB1, WHSC1, POT1, and SMARCA4. We noted that MCLs have a distinct mutational profile compared with lymphomas from other B-cell...

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Source

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Identifiers

PMID: 24682267
DOI: 10.1182/blood-2013-07-517177
PMCID: PMC4014841

Genes

ATM
CCND1
POT1
SMARCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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