Article
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America - 5 Nov 2013
Beà Sílvia, Valdés-Mas Rafael, Navarro Alba, Salaverria Itziar, Martín-Garcia David, Jares Pedro, Giné Eva, Pinyol Magda, Royo Cristina, Nadeu Ferran, Conde Laura, Juan Manel, Clot Guillem, Vizán Pedro, Di Croce Luciano, Puente Diana A, López-Guerra Mónica, Moros Alexandra, Roue Gael, Aymerich Marta, Villamor Neus, Colomo Lluís, Martínez Antonio, Valera Alexandra, Martín-Subero José I, Amador Virginia, Hernández Luis, Rozman Maria, Enjuanes Anna, Forcada Pilar, Muntañola Ana, Hartmann Elena M, Calasanz María J, Rosenwald Andreas, Ott German, Hernández-Rivas Jesús M, Klapper Wolfram, Siebert Reiner, Wiestner Adrian, Wilson Wyndham H, Colomer Dolors, López-Guillermo Armando, López-Otín Carlos, Puente Xose S, Campo Elías
Abstract excerpt
Mantle cell lymphoma (MCL) is an aggressive tumor, but a subset of patients may follow an indolent clinical course. To understand the mechanisms underlying this biological heterogeneity, we performed whole-genome and/or whole-exome sequencing on 29 MCL cases and their respective matched normal DNA, as well as 6 MCL cell lines. Recurrently mutated genes were investigated by targeted sequencing in an independent...
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