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Article

The triumph of good over evil: protection by the sickle gene against malaria.

Blood - 3 Jan 2013

Bunn H Franklin

Abstract excerpt

The mechanisms underlying Plasmodium falciparum resistance in persons with sickle trait have been under active investigation for more than a half century. This Perspective reviews progress in solving this challenging problem, including recent studies that have exploited the genomics and proteomics of the parasite. The formation of Hb S polymer in the parasitized AS RBC leads to impaired parasite growth and...

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Share to Erythrocyte Membrane
Share to Erythrocytes, Abnormal
Share to Glucosephosphate Dehydrogenase Deficiency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heme Oxygenase-1

Share to Hemoglobin, Sickle

Share to Plasmodium berghei

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Source

Identifiers

PMID: 23118217
DOI: 10.1182/blood-2012-08-449397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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