Article

Geographical variation drives adaptive equilibrium of the <i>P. falciparum</i> sickle-associated mutations

2025-09-04

Abstract excerpt

The recent discovery of genetic mutations in Plasmodium falciparum —the most lethal malaria parasite—that enable it to overcome the protective effects of sickle cell trait, raises fundamental questions about the underlying biological and evolutionary interactions. Here we develop a geostatistical model to compare sickle haemoglobin genotype frequencies to the Plasmodium falciparum sickle-associated alleles acros...

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Literature Corpus work: 011f1f92-69aa-5471-8a74-6916115db4e6
DOI: 10.1101/2025.08.31.672853

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