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Article

Structural basis of trehalose recognition by the mycobacterial LpqY-SugABC transporter.

The Journal of biological chemistry - 1 Jan 2000

Furze Christopher M, Delso Ignacio, Casal Enriqueta, Guy Collette S, Seddon Chloe, Brown Chelsea M, Parker Hadyn L, Radhakrishnan Anjana, Pacheco-Gomez Raul, Stansfeld Phillip J, Angulo Jesus, Cameron Alexander D, Fullam Elizabeth

Abstract excerpt

The Mycobacterium tuberculosis (Mtb) LpqY-SugABC ATP-binding cassette transporter is a recycling system that imports trehalose released during remodeling of the Mtb cell-envelope. As this process is essential for the virulence of the Mtb pathogen, it may represent an important target for tuberculosis drug and diagnostic development, but the transporter specificity and molecular determinants of substrate...

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ATP-Binding Cassette Transporters
Cell Wall
Molecular Dynamics Simulation
Protein Conformation, alpha-Helical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation, beta-Strand

Protein Interaction Domains and Motifs

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Identifiers

PMID: 33476646
DOI: 10.1016/j.jbc.2021.100307
PMCID: PMC7949145

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