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Polarly localized EccE <sub>1</sub> is required for ESX-1 function and stabilization of ESX-1 membrane proteins in <i>Mycobacterium tuberculosis</i>

2019-10-30

Abstract excerpt

<h4>ABSTRACT</h4> Mycobacterium tuberculosis is a slow-growing intracellular bacterium with the ability to induce host cell death and persist indefinitely in the human body. This pathogen uses the specialized ESX-1 secretion system to secrete virulence factors and potent immunogenic effectors required for disease progression. ESX-1 is a multi-subunit apparatus with a membrane complex that is predicted to form a p...

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Literature Corpus work
78d8613f-24f8-56c9-bc60-d360dbab51c2
DOI
10.1101/820324
Open publication

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