Article
Targeting trehalose and methylglucose lipopolysaccharide biosynthetic pathways in M. tuberculosis : structural and functional characterisation, and early-stage drug discovery of OtsA and Rv3030
2016-01-01
Abstract excerpt
Mycobacterium tuberculosis, the causative agent of tuberculosis in humans, is one of the most successful pathogens, with much of its virulence predominantly associated with its thick, lipid rich cellular envelope that modulates the host immune response. Tuberculosis, having a long history, has proved to be a challenging disease to eradicate. In mycobacteria, trehalose occurs as a free sugar in the cytoplasm, as we...
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Identifiers and source
- Literature Corpus work
- 990b6a93-8372-534e-a117-2897469ce248
- DOI
- 10.17863/cam.13754