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Genetics of Mycobacterial Trehalose Metabolism

2 May 2014

Abstract excerpt

Trehalose [alpha-D-glucopyranosyl-(1→1)-alpha-D-glucopyranoside] is a highly abundant disaccharide in mycobacteria that fulfills many biological roles and has a plethora of possible metabolic fates. Trehalose is synthesized in mycobacteria de novo either from glycolytic intermediates or from alpha-glucans via two alternative routes, the OtsA-OtsB and the TreY-TreZ pathways, respectively. Intracellular trehalose...

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PMID: 26103976
DOI: 10.1128/microbiolspec.mgm2-0002-2013

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