Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CHIP-associated mutant ASXL1 in blood cells promotes solid tumor progression.

Cancer science - 1 Apr 2022

Liu Xiaoxiao, Sato Naru, Shimosato Yuko, Wang Teh-Wei, Denda Tamami, Chang Yu-Hsuan, Yabushita Tomohiro, Fujino Takeshi, Asada Shuhei, Tanaka Yosuke, Fukuyama Tomofusa, Enomoto Yutaka, Ota Yasunori, Sakamoto Takeharu, Kitamura Toshio, Goyama Susumu

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-associated phenomenon characterized by clonal expansion of blood cells harboring somatic mutations in hematopoietic genes, including DNMT3A, TET2, and ASXL1. Clinical evidence suggests that CHIP is highly prevalent and associated with poor prognosis in solid-tumor patients. However, whether blood cells with CHIP mutations play a causal role in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Clonal Hematopoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Neoplasms

Share to Repressor Proteins

Share to Transcription Factors

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 35133065
DOI: 10.1111/cas.15294
PMCID: PMC8990791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHIP-associated mutant ASXL1 in blood cells promotes solid tumor progression.PMID 35133065Read ↗

CHIP Happens: Clonal Hematopoiesis of Indeterminate Potential and Its Relationship to Solid Tumors.Semantic proximity Read ↗

Clonal Hematopoiesis of Indeterminate Potential in Patients with Solid Tumor Malignancies.Semantic proximity Read ↗

MYD88 mutations in clonal hematopoiesis promote inflammation and hematopoietic stem cell expansionSemantic proximity Read ↗

Clonal Hematopoiesis of Indeterminate Potential Influences Breast Cancer Outcomes in a Genotype-Specific Manner.Semantic proximity Read ↗

Gene-Specific Analysis of Clonal Hematopoiesis Identifies ASXL1 as a Risk Factor for Lung CancerSemantic proximity Read ↗

ASXL1 mutation-related clonal hematopoiesis and age-related diseases: clinical evidence and molecular insightsSemantic proximity Read ↗

Role of ASXL1 in hematopoiesis and myeloid diseases.Semantic proximity Read ↗

Tumor-Infiltrating Clonal HematopoiesisSemantic proximity Read ↗

An inside job-CHIP infiltrates and promotes cancer.Semantic proximity Read ↗

Current Understanding of CHIP's Immunobiological Footprint with A Focus on Gastrointestinal Disorders: A Review of the Literature.Semantic proximity Read ↗

CH-related Mutant ASXL1 Promotes Atherosclerosis in Mice via Dysregulated Innate ImmunitySemantic proximity Read ↗

The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.