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Article

Clonal Hematopoiesis of Indeterminate Potential in Patients with Solid Tumor Malignancies.

Cancer research - 15 Nov 2022

Marshall Catherine H, Gondek Lukasz P, Luo Jun, Antonarakis Emmanuel S

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) refers to the expansion of cells of hematopoietic lineage that carry acquired somatic alterations associated with hematologic malignancies. The most commonly altered genes giving rise to CHIP are DNMT3A, TET2, and ASXL1. However, advanced sequencing technologies have resulted in highly sensitive detection of clonal hematopoiesis beyond these known driver...

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Mutation
Acute Myeloid Leukemia Research
Clonal Hematopoiesis
Erythrocyte Function and Pathophysiology
Hematologic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hematopoietic Stem Cells

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Identifiers

PMID: 36040522
DOI: 10.1158/0008-5472.CAN-22-0985
PMCID: PMC9669303

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