Clonal Hematopoiesis of Indeterminate Potential Influences Breast Cancer Outcomes in a Genotype-Specific Manner.

doi:10.1158/1078-0432.CCR-25-2009

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Clonal Hematopoiesis of Indeterminate Potential Influences Breast Cancer Outcomes in a Genotype-Specific Manner.

Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Nov 2025

Reed Sarah C, Potts Chad R, Luo Leo Y, Davidson Brad A, Bergman Riley E, Kemp Justin D J, Fox Ethan K, Thomas Bryce A, Ha Lauren, Arora Vani, Cartailler Justin, Sanders Melinda E, Sanchez Violeta, Gonzalez-Ericsson Paula, Croessmann Sarah, Hurley Paula J, Bick Alexander G, Ferrell P Brent, Park Ben Ho

Abstract excerpt

PURPOSE: Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with adverse outcomes in some solid tumor settings, but its impact on breast cancer remains unclear. We sought to investigate the genotype-specific effects of CHIP on breast cancer outcomes and the tumor microenvironment. EXPERIMENTAL DESIGN: We examined a retrospective cohort of 125 patients with breast cancer, using targeted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clonal Hematopoiesis

Share to Dioxygenases

Share to Disease Models, Animal

Share to DNA (Cytosine-5-)-Methyltransferases

Share to DNA Methyltransferase 3A

Share to Proto-Oncogene Proteins

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 40970771
DOI: 10.1158/1078-0432.CCR-25-2009
PMCID: PMC13021136

Genes

DNMT3A
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal Hematopoiesis of Indeterminate Potential Influences Breast Cancer Outcomes in a Genotype-Specific Manner.PMID 40970771Read ↗

Impact of Clonal Hematopoiesis of Indeterminate Potential on Treatment Response and Tumor Microenvironment in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy.Semantic proximity Read ↗

Prevalence, Dynamics, and Prognostic Role of Clonal Hematopoiesis of Indeterminate Potential in Patients With Breast Cancer.Semantic proximity Read ↗

Clonal hematopoiesis is enriched in melanoma and associated with genotype-specific differences in tumor growth and survivalSemantic proximity Read ↗

Tumor-Infiltrating Clonal HematopoiesisSemantic proximity Read ↗

Association of clonal hematopoiesis and mosaic chromosomal alterations with solid malignancy incidence and mortalitySemantic proximity Read ↗

Clonal Hematopoiesis in Young Women Treated for Breast Cancer.Semantic proximity Read ↗

CHIP Happens: Clonal Hematopoiesis of Indeterminate Potential and Its Relationship to Solid Tumors.Semantic proximity Read ↗

Clonal Hematopoiesis of Indeterminate Potential in Patients with Solid Tumor Malignancies.Semantic proximity Read ↗

A real-world data analysis of the impact of clonal hematopoiesis of indeterminate potential on therapeutic efficacy and adverse events of immune checkpoint inhibitors.Semantic proximity Read ↗

CHIP-associated mutant ASXL1 in blood cells promotes solid tumor progression.Semantic proximity Read ↗

Causal association between clonal hematopoiesis indeterminate potential and cancer: a Mendelian randomization study.Semantic proximity Read ↗

MYD88 mutations in clonal hematopoiesis promote inflammation and hematopoietic stem cell expansionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.