Article
Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.
The Journal of experimental medicine - 4 Jun 2018
Nagase Reina, Inoue Daichi, Pastore Alessandro, Fujino Takeshi, Hou Hsin-An, Yamasaki Norimasa, Goyama Susumu, Saika Makoto, Kanai Akinori, Sera Yasuyuki, Horikawa Sayuri, Ota Yasunori, Asada Shuhei, Hayashi Yasutaka, Kawabata Kimihito Cojin, Takeda Reina, Tien Hwei-Fang, Honda Hiroaki, Abdel-Wahab Omar, Kitamura Toshio
Abstract excerpt
Additional sex combs like 1 (ASXL1) is frequently mutated in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes hematopoietic transformation, there is growing evidence that ASXL1 mutations might confer an alteration of function. In this study, we identify that physiological expression of a C-terminal truncated Asxl1 mutant in vivo using conditional...
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