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Article

An inside job-CHIP infiltrates and promotes cancer.

Immunity - 10 Jun 2025

Soong Brian Y, Yatim Nader, Merad Miriam

Abstract excerpt

Somatic mutations in hematopoietic stem cells can lead to clonal hematopoiesis of indeterminate potential (CHIP), a frequent condition associated with many age-related diseases including solid cancer. In the New England Journal of Medicine, Pich et al. report that tumor-infiltrating CHIP correlates with worsened cancer prognosis and clinical outcomes, providing evidence for the impact of mutated immune cells on...

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PMID: 40499517
DOI: 10.1016/j.immuni.2025.05.014

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