Article
Polymorphic mutations in the polb gene promoter and their impact on transcriptional activity.
Thoracic cancer - 1 Mar 2022
Wu Qingjun, Qi Yuying, Wang Shuanghu, Liu Jian, Geng Peiwu, Zhou Quan, Zhang Wenqian, Cai Jianping, Hu Bin, Dai Dapeng, Li Hui
Abstract excerpt
BACKGROUND: DNA polymerase β is one of the key enzymes involved in DNA damage repair and its proper expression is strictly controlled within different cells. We previously reported that three genetic mutations in the promoter region of the polb gene are prevalent in the Chinese Han population and two types of mutation are associated with thymic hyperplasia. The purpose of this study was to explore whether other...
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