Article
Analysis of Cancer-Associated Mutations of POLB Using Machine Learning and Bioinformatics.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Alkhanbouli Razan, Al-Aamri Amira, Maalouf Maher, Taha Kamal, Henschel Andreas, Homouz Dirar
Abstract excerpt
DNA damage is a critical factor in the onset and progression of cancer. When DNA is damaged, the number of genetic mutations increases, making it necessary to activate DNA repair mechanisms. A crucial factor in the base excision repair process, which helps maintain the stability of the genome, is an enzyme called DNA polymerase β (Pol β) encoded by the POLB gene. It plays a vital role in the repair of damaged...
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