Article
Two polymorphic mutations in promoter region of DNA polymerase β in relatively higher percentage of thymic hyperplasia patients.
Thoracic cancer - 1 Mar 2021
Wu Qingjun, Zhou Shan, Liu Jian, Tong Hongfeng, Sun Yaoguang, Tian Wenxin, Yu Hanbo, Huang Chuan, Li Donghang, Jiao Peng, Ma Chao, Cai Jianping, Dai Dapeng
Abstract excerpt
BACKGROUND: DNA polymerase β is one of the key enzymes involved in the repair of DNA damage, and its high or low expression is closely related to tumorigenesis. In a previous study on lung cancer, we found three genetic mutations in the promoter region of the Polb gene could be detected in the Han Chinese population. The purpose of this study was to explore the relationship between these mutations and thymic...
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