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Article

Relationships between bronchodilator responsiveness, a COPD polygenic risk score, and COPD progression.

Respiratory medicine - 1 Feb 2026

Fortis Spyridon, Comellas Alejandro P, Bowler Russell P, Bhatt Surya P, Hersh Craig P, Demeo Dawn L, Kinney Gregory, Silverman Edwin K, Cho Michael H, Moll Matthew

Abstract excerpt

INTRODUCTION: Bronchodilator responsiveness (BDR) is associated with progression to COPD. Genetic risk for COPD, summarized by polygenic risk scores (PRS), predicts low lung function and COPD. However, it remains unclear whether genetic predisposition to COPD is related to BDR and whether PRS and BDR together influence lung function decline in individuals at risk for the disease. METHODS: We analyzed data from...

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Black or African American
Bronchodilator Agents
Cross-Sectional Studies
Forced Expiratory Volume
Genetic Risk Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pulmonary Disease, Chronic Obstructive

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PMID: 41520899
DOI: 10.1016/j.rmed.2026.108636
PMCID: PMC12834220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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