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Locus Coeruleus Shows a Spatial Pattern of Structural Disintegration in Parkinson's Disease

3 Feb 2022

Abstract excerpt

ABSTRACT Background Parkinson's disease (PD) causes a loss of neuromelanin‐positive, noradrenergic neurons in the locus coeruleus (LC), which has been implicated in nonmotor dysfunction. Objectives We used “neuromelanin sensitive” magnetic resonance imaging (MRI) to localize structural disintegration in the LC and its association with nonmotor dysfunction in PD. Methods A total of 42 patients with PD and 24...

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PMID: 35114035
DOI: 10.1002/mds.28945

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