Article

Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease

2020-09-03

Abstract excerpt

Cognitive decline is a common feature of Parkinson’s disease, and many of these cognitive deficits fail to respond to dopaminergic therapy. Therefore, targeting other neuromodulatory systems represents an important therapeutic strategy. Among these, the locus coeruleus-noradrenaline system has been extensively implicated in response inhibition deficits. Restoring noradrenaline levels using the noradrenergic reupta...

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Literature Corpus work: 794dee9c-fedf-5f19-ab19-dbc3db49b9b4
DOI: 10.1101/2020.09.03.20176800

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