Article

Neuromelanin-sensitive MRI correlates of cognitive and motor function in Parkinson’s disease with freezing of gait

2023-07-06

Abstract excerpt

Substantia nigra pars compacta (SNc) and locus coeruleus (LC) are neuromelanin-rich nuclei implicated in diverse cognitive and motor processes in normal brain function and disease. However, their roles in aging and neurodegenerative disease mechanisms have remained unclear due to a lack of tools to study them in vivo . Preclinical and post-mortem human investigations indicate that the relationship between tissue n...

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Literature Corpus work: 0c7c3302-7488-5d73-8455-b784f748205d
DOI: 10.1101/2023.07.04.23292227

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