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Article

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

11 Jun 2019

Abstract excerpt

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease progression. In combination with neuropathological biomarkers, in vivo locus coeruleus imaging could help to understand...

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PMID: 31327002
DOI: 10.1093/brain/awz193

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