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Article

In vivo bone-specific EphB4 overexpression in mice protects both subchondral bone and cartilage during osteoarthritis.

Arthritis and rheumatism - 1 Nov 2012

Valverde-Franco Gladys, Pelletier Jean-Pierre, Fahmi Hassan, Hum David, Matsuo Koichi, Lussier Bertrand, Kapoor Mohit, Martel-Pelletier Johanne

Abstract excerpt

OBJECTIVE: In vitro activation of the receptor EphB4 positively affects human osteoarthritis (OA) articular cell metabolism. However, the specific in vivo role of this ephrin receptor in OA remains unknown. We investigated in mice the in vivo effect of bone-specific EphB4 overexpression on OA pathophysiology. METHODS: Morphometric, morphologic, and radiologic evaluations were performed on postnatal day 5 (P5)...

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Identifiers

PMID: 22833446
DOI: 10.1002/art.34638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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