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Article

Subchondral bone sclerosis and cancellous bone loss following OA induction depend on the underlying bone phenotype.

Joint bone spine - 1 Jan 2017

Osterberg Anja, Thiem Daniel, Herlyn Philipp, Mittlmeier Thomas, Frerich Bernhard, Müller-Hilke Brigitte

Abstract excerpt

OBJECTIVES: Osteoarthritis (OA) is increasingly considered a disease of the whole joint, yet the interplay between the articular cartilage and the subchondral bone remains obscure. We here set out to investigate the impact of bone mass on the progression of surgically induced knee OA in the mouse. METHODS: OA was induced in the right knees of female C57BL/6 (low bone mass) and STR/ort (high bone mass) mice via...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27236261
DOI: 10.1016/j.jbspin.2015.11.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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