Article
Cartilage-specific deletion of ephrin-B2 in mice results in early developmental defects and an osteoarthritis-like phenotype during aging in vivo.
Arthritis research & therapy - 15 Mar 2016
Valverde-Franco Gladys, Lussier Bertrand, Hum David, Wu Jiangping, Hamadjida Adjia, Dancause Numa, Fahmi Hassan, Kapoor Mohit, Pelletier Jean-Pierre, Martel-Pelletier Johanne
Abstract excerpt
BACKGROUND: Ephrins and their related receptors have been implicated in some developmental events. We have demonstrated that ephrin-B2 (EFNB2) could play a role in knee joint pathology associated with osteoarthritis (OA). Here, we delineate the in vivo role of EFNB2 in musculoskeletal growth, development, and in OA using a cartilage-specific EFNB2 knockout (EFNB2(Col2)KO) mouse model. METHODS: EFNB2(Col2)KO was...
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