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Article

Sirt6 regulates lifespan in <i>Drosophila melanogaster</i>

28 Jan 2022

Abstract excerpt

Significance Sirt6 is well known for its role in regulating the aging process, particularly for its ability to extend lifespan in mice when overexpressed. However, the underlying molecular mechanisms responsible for lifespan regulation by Sirt6 are not well understood. Here, we characterized dSirt6 in fruit flies ( Drosophila melanogaster ). We found that dSirt6 functions very similarly to mammalian Sirt6 at the...

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PMID: 35091469
DOI: 10.1073/pnas.2111176119

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