Article
Characterization of physiological defects in adult SIRT6-/- mice.
PloS one - 1 Jan 2017
Peshti Victoria, Obolensky Alexey, Nahum Liat, Kanfi Yariv, Rathaus Moran, Avraham Maytal, Tinman Simon, Alt Fredrick W, Banin Eyal, Cohen Haim Y
Abstract excerpt
The NAD+-dependent SIRT6 deacetylase was shown to be a major regulator of lifespan and healthspan. Mice deficient for SIRT6 develop a premature aging phenotype and metabolic defects, and die before four weeks of age. Thus, the effect of SIRT6 deficiency in adult mice is unknown. Here we show that SIRT6-/- mice in mixed 129/SvJ/BALB/c background reach adulthood, allowing examination of SIRT6-related metabolic and...
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