Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT6 is a key regulator of mitochondrial function in the brain

18 Jan 2023

Abstract excerpt

The SIRT6 deacetylase has been implicated in DNA repair, telomere maintenance, glucose and lipid metabolism and, importantly, it has critical roles in the brain ranging from its development to neurodegeneration. Here, we combined transcriptomics and metabolomics approaches to characterize the functions of SIRT6 in mouse brains. Our analysis reveals that SIRT6 is a central regulator of mitochondrial activity in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mitochondrial Function and Pathology
Share to Sirtuins and Resveratrol in Medicine
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36653345
DOI: 10.1038/s41419-022-05542-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT6 is a key regulator of mitochondrial function in the brainPMID 36653345Read ↗

SIRT6 is a key regulator of mitochondrial function in the brainSemantic proximity Read ↗

SIRT6 is a key regulator of mitochondrial function in the brainSemantic proximity Read ↗

A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic TargetsSemantic proximity Read ↗

SIRT3: A Central Regulator of Mitochondrial Adaptation in Health and DiseaseSemantic proximity Read ↗

Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative DiseaseSemantic proximity Read ↗

Aging and pathological aging signatures of the brain: through the focusing lens of SIRT6Semantic proximity Read ↗

Mitochondrial sirtuins, key regulators of agingSemantic proximity Read ↗

SIRT3 regulates mitochondrial biogenesis in aging-related diseasesSemantic proximity Read ↗

Neuroprotective Functions for the Histone Deacetylase SIRT6.Semantic proximity Read ↗

SIRT1: new avenues of discovery for disorders of oxidative stressSemantic proximity Read ↗

SIRT1 and SIRT6: The role in aging-related diseasesSemantic proximity Read ↗

Function of the SIRT 3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.