Article
SIRT6 is a key regulator of mitochondrial function in the brain
2022-11-08
Abstract excerpt
SIRT6 is implicated in DNA repair, telomere maintenance, glucose and lipid metabolism and, importantly, it has critical roles in the brain ranging from its development to neurodegeneration. In this work, we combined transcriptomics and metabolomics approaches to characterize the functions of SIRT6 in mice brains. Our analysis revealed that SIRT6 is a critical regulator of mitochondrial activity in the brain. In it...
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Identifiers and source
- Literature Corpus work
- d88388d0-4715-51d9-95e6-f79076a8a5e0
- DOI
- 10.1101/2022.11.08.515572