Article
Trans-ancestral fine-mapping of MHC reveals key amino acids associated with spontaneous clearance of hepatitis C in HLA-DQβ1.
American journal of human genetics - 3 Feb 2022
Valencia Ana, Vergara Candelaria, Thio Chloe L, Vince Nicolas, Douillard Venceslas, Grifoni Alba, Cox Andrea L, Johnson Eric O, Kral Alex H, Goedert James J, Mangia Alessandra, Piazzolla Valeria, Mehta Shruti H, Kirk Gregory D, Kim Arthur Y, Lauer Georg M, Chung Raymond T, Price Jennifer C, Khakoo Salim I, Alric Laurent, Cramp Matthew E, Donfield Sharyne M, Edlin Brian R, Busch Michael P, Alexander Graeme, Rosen Hugo R, Murphy Edward L, Wojcik Genevieve L, Carrington Mary, Gourraud Pierre-Antoine, Sette Alessandro, Thomas David L, Duggal Priya
Abstract excerpt
Spontaneous clearance of acute hepatitis C virus (HCV) infection is associated with single nucleotide polymorphisms (SNPs) on the MHC class II. We fine-mapped the MHC region in European (n = 1,600; 594 HCV clearance/1,006 HCV persistence) and African (n = 1,869; 340 HCV clearance/1,529 HCV persistence) ancestry individuals and evaluated HCV peptide binding affinity of classical alleles. In both populations,...
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