Article
Host genetics and immune control of HIV-1 infection: fine mapping for the extended human MHC region in an African cohort.
Genes and immunity - 1 Jan 2000
Prentice H A, Pajewski N M, He D, Zhang K, Brown E E, Kilembe W, Allen S, Hunter E, Kaslow R A, Tang J
Abstract excerpt
Multiple major histocompatibility complex (MHC) loci encoding human leukocyte antigens (HLA) have allelic variants unequivocally associated with differential immune control of HIV-1 infection. Fine mapping based on single nucleotide polymorphisms (SNPs) in the extended MHC (xMHC) region is expected to reveal causal or novel factors and to justify a search for functional mechanisms. We have tested the utility of a...
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