Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Associations between the human MHC and sustained virologic response in the treatment of chronic hepatitis C virus infection.

Genes and immunity - 1 Jun 2008

Rhodes S L, Erlich H, Im K A, Wang J, Li J, Bugawan T, Jeffers L, Tong X, Su X, Rosen H R, Yee L J, Liang T J, Yang H

Abstract excerpt

The human major histocompatability complex (MHC) genes encode the human leukocyte antigens, which are important in antigen presentation and regulation of CD8+ and CD4+ T cells. Response to therapies in hepatitis C virus (HCV) infection is highly variable (30-80%) and lower response rates have been reported among African Americans (AA; approximately 30%) compared to Caucasian Americans (CA; approximately 50%)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Drug Therapy, Combination

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, MHC Class I

Share to Genes, MHC Class II

Share to Interferon-alpha

Share to Interferon alpha-2

Share to Polyethylene Glycols

Share to Ribavirin

Source

Open in PubMed Open full text

Identifiers

PMID: 18418397
DOI: 10.1038/gene.2008.21
PMCID: PMC2696808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Associations between the human MHC and sustained virologic response in the treatment of chronic hepatitis C virus infection.PMID 18418397Read ↗

Polymorphism in the human major histocompatibility complex and early viral decline during treatment of chronic hepatitis C.Semantic proximity Read ↗

Human leukocyte antigen–associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution†Semantic proximity Read ↗

Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans.Semantic proximity Read ↗

HLA class II associated with outcomes of hepatitis B and C infectionsSemantic proximity Read ↗

Polymorphisms of HLA-DM on Treatment Response to Interferon/Ribavirin in Patients with Chronic Hepatitis C Virus Type 1 Infection.Semantic proximity Read ↗

The MHC is a major determinant of viral status, but not fibrotic stage, in individuals infected with hepatitis C.Semantic proximity Read ↗

Human leukocyte antigen class I alleles can predict response to pegylated interferon/ribavirin therapy in chronic hepatitis C Egyptian patients.Semantic proximity Read ↗

Associations of human leucocyte antigen class II-DQB1 alleles with hepatitis C virus infection in Egyptian population: a multicentre family-based study.Semantic proximity Read ↗

Ethnic and geographical differences in HLA associations with the outcome of hepatitis C virus infection.Semantic proximity Read ↗

HLA class I allele associations with HCV genetic variants in patients with chronic HCV genotypes 1a or 1b infection.Semantic proximity Read ↗

Trans-ancestral fine-mapping of MHC reveals key amino acids associated with spontaneous clearance of hepatitis C in HLA-DQβ1.Semantic proximity Read ↗

Specific human leukocyte antigen class I and II alleles associated with hepatitis C virus viremia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.