Article
Multi-ancestry fine mapping of interferon lambda and the outcome of acute hepatitis C virus infection.
Genes and immunity - 1 Nov 2020
Vergara Candelaria, Duggal Priya, Thio Chloe L, Valencia Ana, O'Brien Thomas R, Latanich Rachel, Timp Winston, Johnson Eric O, Kral Alex H, Mangia Alessandra, Goedert James J, Piazzola Valeria, Mehta Shruti H, Kirk Gregory D, Peters Marion G, Donfield Sharyne M, Edlin Brian R, Busch Michael P, Alexander Graeme, Murphy Edward L, Kim Arthur Y, Lauer Georg M, Chung Raymond T, Cramp Matthew E, Cox Andrea L, Khakoo Salim I, Rosen Hugo R, Alric Laurent, Wheelan Sarah J, Wojcik Genevieve L, Thomas David L, Taub Margaret A
Abstract excerpt
Clearance of acute infection with hepatitis C virus (HCV) is associated with the chr19q13.13 region containing the rs368234815 (TT/ΔG) polymorphism. We fine-mapped this region to detect possible causal variants that may contribute to HCV clearance. First, we performed sequencing of IFNL1-IFNL4 region in 64 individuals sampled according to rs368234815 genotype: TT/clearance (N = 16) and ΔG/persistent (N = 15)...
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