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Article

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.

Scientific reports - 20 Nov 2017

Huang Hailiang, Duggal Priya, Thio Chloe L, Latanich Rachel, Goedert James J, Mangia Alessandra, Cox Andrea L, Kirk Gregory D, Mehta Shruti, Aneja Jasneet, Alric Laurent, Donfield Sharyne M, Cramp Matthew E, Khakoo Salim I, Tobler Leslie H, Busch Michael, Alexander Graeme J, Rosen Hugo R, Edlin Brian R, Segal Florencia P, Lauer Georg M, Thomas David L, Daly Mark J, Chung Raymond T, Kim Arthur Y

Abstract excerpt

Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously...

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Identifiers

PMID: 29158528
DOI: 10.1038/s41598-017-16011-2
PMCID: PMC5696522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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