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HLA-DQB1*03:01 and risk of HBV-related HCC.

Hepatology (Baltimore, Md.) - 1 Feb 2026

Zhang Ting, Huang Chih-Jen, Chen Hai-Tao, Huang Yu-Han, Pan Mei-Hung, Lee Mei-Hsuan, Viard Mathias, Hildesheim Allan, Pfeiffer Ruth M, Carrington Mary, Chen Chien-Jen, Zhu Bin, Lenz Tobias L, Jiang Deke, Yang Hwai-I, Liu Zhiwei

Abstract excerpt

BACKGROUND AND AIMS: The human leukocyte antigen (HLA) locus is implicated in HCC among chronic HBV carriers. We investigated associations of HLA variants, amino acid polymorphisms, zygosity, and evolutionary divergence with HBV-related HCC in Han Chinese and explored biological mechanisms. APPROACH AND RESULTS: We examined the associations of HLA variants (imputed 4-digit classical alleles and amino acid...

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Identifiers

PMID: 40084945
DOI: 10.1097/HEP.0000000000001307
PMCID: PMC12353533

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