Article
Fine mapping the MHC region identified four independent variants modifying susceptibility to chronic hepatitis B in Han Chinese.
Human molecular genetics - 15 Mar 2016
Zhu Meng, Dai Juncheng, Wang Cheng, Wang Yuzhuo, Qin Na, Ma Hongxia, Song Ci, Zhai Xiangjun, Yang Yuan, Liu Jibin, Liu Li, Li Shengping, Liu Jianjun, Yang Haitao, Zhu Fengcai, Shi Yongyong, Shen Hongbing, Jin Guangfu, Zhou Weiping, Hu Zhibin
Abstract excerpt
Several genome-wide association studies (GWAS) have demonstrated the association between genetic variants in the major histocompatibility complex (MHC) region and chronic hepatitis B (CHB) virus infection, but it is still unknown about the disease-causing loci and potential mechanisms owing to the complicated linkage disequilibrium for this region. To systematically characterize the MHC variations in relation to...
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