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Article

A comparative study of next-generation sequencing and fragment analysis for the detection and allelic ratio determination of FLT3 internal tandem duplication.

Diagnostic pathology - 26 Jan 2022

Kim Jin Ju, Lee Kwang Seob, Lee Taek Gyu, Lee Seungjae, Shin Saeam, Lee Seung-Tae

Abstract excerpt

BACKGROUND: Currently, FLT3 internal tandem duplication (ITD) is tested by fragment analysis. With next-generation sequencing (NGS), however, not only FLT3 ITD but also other mutations can be detected, which can provide more genetic information on disease. METHODS: We retrospectively reviewed the results of two tests-fragment analysis and a custom-designed, hybridization capture-based, targeted NGS...

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Source

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Identifiers

PMID: 35081962
DOI: 10.1186/s13000-022-01202-x
PMCID: PMC8790841

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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