Article
Targeted Informatics for Optimal Detection, Characterization, and Quantification of FLT3 Internal Tandem Duplications Across Multiple Next-Generation Sequencing Platforms.
The Journal of molecular diagnostics : JMD - 1 Sept 2020
Tsai Harrison K, Brackett Diane G, Szeto David, Frazier Ryan, MacLeay Allison, Davineni Phani, Manning Danielle K, Garcia Elizabeth, Lindeman Neal I, Le Long P, Lennerz Jochen K, Gibson Christopher J, Lindsley R Coleman, Kim Annette S, Nardi Valentina
Abstract excerpt
Assessment of internal tandem duplications in FLT3 (FLT3-ITDs) and their allelic ratio (AR) is recommended by clinical guidelines for diagnostic workup of acute myeloid leukemia and traditionally performed through capillary electrophoresis (CE). Although significant progress has been made integrating FLT3-ITD detection within contemporary next-generation sequencing (NGS) panels, AR estimation is not routinely...
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