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Technological Advances: CEBPA and FLT3 Internal Tandem Duplication Mutations Can be Reliably Detected by Next Generation Sequencing.

Genes - 1 Apr 2022

Akabari Ratilal, Qin Dahui, Hussaini Mohammad

Abstract excerpt

BACKGROUND: The detection of CEBPA and FLT3 mutations by next generation sequencing (NGS) is challenging due to high GC content and Internal Tandem Duplications (ITDs). Recent advances have been made to surmount these challenges. In this study, we compare three commercial kits and evaluate the performance of these more advanced hybrid-capture and AMP-chemistry based methods. METHODS: Amplicon-based TSM 54-Gene...

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Identifiers

PMID: 35456436
DOI: 10.3390/genes13040630
PMCID: PMC9028339

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