Article
Detection of FLT3 internal tandem duplication in targeted, short-read-length, next-generation sequencing data.
The Journal of molecular diagnostics : JMD - 1 Jan 2013
Spencer David H, Abel Haley J, Lockwood Christina M, Payton Jacqueline E, Szankasi Philippe, Kelley Todd W, Kulkarni Shashikant, Pfeifer John D, Duncavage Eric J
Abstract excerpt
A recurrent somatic mutation frequently found in cytogenetically normal acute myeloid leukemia (AML) is internal tandem duplication (ITD) in the fms-related tyrosine kinase 3 gene (FLT3). This mutation is generally detected in the clinical laboratory by PCR and electrophoresis-based product sizing. As the number of clinically relevant somatic mutations in AML increases, it becomes increasingly attractive to...
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