Article

Identification of a transcriptional signature found in multiple models of ASD and related disorders

2022-01-15

Abstract excerpt

Epigenetic regulation plays a critical role in many neurodevelopmental disorders, including Autism Spectrum Disorder (ASD). In particular, many such disorders are the result of mutations in genes that encode chromatin modifying proteins. However, while these disorders share many features, it is unclear whether they also share gene expression disruptions resulting from the aberrant regulation of chromatin. We exami...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a824439e-12c6-51b3-bd9b-05594d180c4f
DOI: 10.1101/2022.01.14.476375

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of a transcriptional signature found in multiple models of ASD and related disordersDOI 10.1101/2022.01.14.476375Read

Maintenance of Heterochromatin links Chromatin Modifiers and Neurodevelopment in Autism Spectrum DisorderSemantic proximity Read

Identification of a molecular network regulated by multiple ASD high risk genes.Semantic proximity Read

Autism spectrum disorder risk genes have convergent effects on transcription and neuronal firing patterns in primary neurons.Semantic proximity Read

High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation.Semantic proximity Read

High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiationSemantic proximity Read

Recent progresses in molecular genetics of autism spectrum disorders.Semantic proximity Read

Autism genes converge on microtubule biology and RNA-binding proteins during excitatory neurogenesisSemantic proximity Read

Dysregulation of The Chromatin Environment Leads to Differential Alternative Splicing as A Mechanism Of Disease In a Human Model of Autism Spectrum DisordersSemantic proximity Read

Merging data from genetic and epigenetic approaches to better understand autistic spectrum disorder.Semantic proximity Read

CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells.Semantic proximity Read

Noncoding <i>de novo</i> mutations contribute to autism spectrum disorder via chromatin interactionsSemantic proximity Read

Enhancer-driven gene regulatory network of forebrain human development provides insights into autismSemantic proximity Read