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Article

Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate.

Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2012

Irie Fumitoshi, Badie-Mahdavi Hedieh, Yamaguchi Yu

Abstract excerpt

Heparan sulfate regulates diverse cell-surface signaling events, and its roles in the development of the nervous system recently have been increasingly uncovered by studies using genetic models carrying mutations of genes encoding enzymes for its synthesis. On the other hand, the role of heparan sulfate in the physiological function of the adult brain has been poorly characterized, despite several pieces of...

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Identifiers

PMID: 22411800
DOI: 10.1073/pnas.1117881109
PMCID: PMC3323986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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