Article

Single cell, whole embryo phenotyping of pleiotropic disorders of mammalian development

2022-08-04

Abstract excerpt

Mouse models are a critical tool for studying human diseases, particularly developmental disorders, as well as for advancing our general understanding of mammalian biology. However, it has long been suspected that conventional approaches for phenotyping are insufficiently sensitive to detect subtle defects throughout the developing mouse. Here we set out to establish single cell RNA sequencing (sc-RNA-seq) of the...

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Literature Corpus work: 3ea38ec5-43ca-5fc7-a866-dd0d430e3960
DOI: 10.1101/2022.08.03.500325

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