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An integrated transcriptomic cell atlas of human endoderm-derived organoids

1 May 2025

Abstract excerpt

Human pluripotent stem cells and tissue-resident fetal and adult stem cells can generate epithelial tissues of endodermal origin in vitro that recapitulate aspects of developing and adult human physiology. Here, we integrate single-cell transcriptomes from 218 samples covering organoids and other models of diverse endoderm-derived tissues to establish an initial version of a human endoderm-derived organoid cell...

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PMID: 40355592
DOI: 10.1038/s41588-025-02182-6

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