Article

Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules controlling vertebrate organogenesis

2025-04-08

Abstract excerpt

While vertebrate species are superficially diverse, they share key commonalities in terms of overall morphology, and organ configuration and function. Maintenance of these traits during evolution is partially explained by conservation of critical genes governing embryonic development. However, for conserved genes to deliver consistent developmental outcomes between species, similar gene regulatory programmes and g...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b7be661e-899f-51f7-8102-af81c88c9405
DOI: 10.1101/2025.04.08.647835

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules controlling vertebrate organogenesisDOI 10.1101/2025.04.08.647835Read

Vertebrate Endoderm Development and Organ FormationSemantic proximity Read

Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ developmentSemantic proximity Read

Multiple roles for Med12 in vertebrate endoderm development.Semantic proximity Read

The Haematopoietically-expressed homeobox transcription factor: roles in development, physiology and diseaseSemantic proximity Read

Single cell transcriptomics reveals a signaling roadmap coordinating endoderm and mesoderm diversification during foregut organogenesisSemantic proximity Read

Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes.Semantic proximity Read

Organ-specific requirements for Hdac1 in liver and pancreas formation.Semantic proximity Read

Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmesSemantic proximity Read

A comparative study of endoderm differentiation in humans and chimpanzeesSemantic proximity Read

Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes.Semantic proximity Read

The gastrointestinal development ‘parts list’: transcript profiling of embryonic gut development in wildtype and <i>Ret</i> -deficient miceSemantic proximity Read

Single-cell analysis of shared signatures and transcriptional diversity during zebrafish developmentSemantic proximity Read