Multi-omics analysis reveals a crucial role for Retinoic Acid in promoting epigenetic and transcriptional competence of an <i>in vitro</i> model of human Pharyngeal Endoderm

Abstract excerpt

<h4>ABSTRACT</h4> In vitro differentiation of human Pluripotent Stem Cells (hPSCs) into different cell types has enabled the study of developmental processes that are impossible to dissect in vivo . This innovation has allowed for the derivation of therapeutically relevant cell types that can be used for downstream applications and studies. The Pharyngeal Endoderm (PE) is considered an extremely relevant develop...

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• Cancer Cells and Metastasis
• Cardiomyopathy and Myosin Studies
• Cardiovascular Function and Risk Factors
• Congenital Diaphragmatic Hernia Studies
• Congenital heart defects research
• Neonatal Respiratory Health Research
• Single-cell and spatial transcriptomics
• Tracheal and airway disorders

Identifiers and source

Literature Corpus work

f8229934-f057-5db8-9a26-f449af990aca

DOI

10.1101/2022.06.26.497457