Article

Regionalized cell and gene signatures govern oesophageal epithelial homeostasis

2024-02-21

Abstract excerpt

Regionalized disease prevalence is a common feature of the gastrointestinal tract. Herein, we employed regionally resolved Smart-seq3 single-cell sequencing, generating a comprehensive cell atlas of the adult mouse oesophagus. Characterizing the oesophageal axis, we unveil non-uniform distribution of epithelial basal cells, fibroblasts and immune cells. In addition, we reveal a position-dependent, but cell subpopu...

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Literature Corpus work: f3fbe73a-e441-5efa-9323-9fc5fbf04828
DOI: 10.1101/2024.02.21.581361

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