Article
Personalized HLA typing leads to the discovery of novel HLA alleles and tumor-specific HLA variants.
HLA - 1 Apr 2022
Anzar Irantzu, Sverchkova Angelina, Samarakoon Pubudu, Ellingsen Espen Basmo, Gaudernack Gustav, Stratford Richard, Clancy Trevor
Abstract excerpt
Accurate and full-length typing of the HLA region is important in many clinical and research settings. With the advent of next generation sequencing (NGS), several HLA typing algorithms have been developed, including many that are applicable to whole exome sequencing (WES). However, most of these solutions operate by providing the closest-matched HLA allele among the known alleles in IPD-IMGT/HLA Database. These...
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