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Article

Assessment of Functional Status of Human Leukocyte Antigen Class I Genes in Cancer Tissues in the Context of Personalized Neoantigen Peptide Vaccine Immunotherapy.

JCO clinical cancer informatics - 1 Jul 2025

Padul Vijay G, Biswas Nupur, Gill Mini, Perez Jesus A, Lopez Javier J, Kesari Santosh, Ashili Shashanka

Abstract excerpt

PURPOSE: Accurate human leukocyte antigen (HLA) typing is an essential step for designing peptide vaccines used in the personalized neoantigen peptide vaccine immunotherapy (PNPVT) in patients with cancer. The reasons for variation in the patient response to PNPVT are yet unknown. One of the reasons could be the somatic changes in the HLA genes in the cancer cells. The objective of the present research was to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40601881
DOI: 10.1200/CCI-24-00174
PMCID: PMC12233180

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